Hi phpAddict, thank you for your reply.
I realize you can install anything on CentOS. My original question is if someone has actual experience they can share about whether Flask plays well with a KH managed VPS package.
See, installing is one thing, but there are lots of places where things could go wrong.
For instance, a Python app doesn't serve pages in the same way as a PHP script. It uses the WSGI interface, which means hooks are needed for the app to serve through Apache.
So we need mod_wsgi. Every time Apache is rebuilt (say for a PHP or MySQL upgrade), playing well would mean that mod_wsgi is automatically reinstalled (it's saved in the settings). Not playing well means you have to install it manually.
And how will it interact with nginx?
This is just one example of many about what it might mean to "play well".